NAD+: The Unsung Hero of DNA Repair

DNA Repair Journey

NAD+, a vital coenzyme found in every living cell, plays a crucial role in numerous cellular processes, including the critical task of DNA repair.¹

As our cells are constantly exposed to damaging agents like radiation, toxins, and oxidative stress, DNA damage is inevitable.²

Fortunately, our bodies have intricate mechanisms to detect and repair this damage, and NAD+ is a key player in this process.³

The Role of NAD+ in DNA Repair

One of the primary ways NAD+ contributes to DNA repair is through its involvement with the enzyme PARP1 (Poly(ADP-ribose) polymerase 1).⁴

When DNA damage occurs, PARP1 utilizes NAD+ to add a chemical tag called ADP-ribose to itself and other proteins involved in the repair process.⁵

This tagging process helps recruit repair enzymes to the damaged site, facilitating efficient repair.⁶

Additionally, NAD+ supports DNA repair by activating sirtuins, a family of proteins with deacetylase activity.⁷

Sirtuins play a role in various cellular processes, including DNA repair, by removing acetyl groups from proteins involved in DNA repair pathways.⁸

This deacetylation process can enhance the activity of these proteins, promoting efficient DNA repair.

The Connection Between NAD+ and Aging

As we age, our NAD+ levels naturally decline, which can impair DNA repair capacity.⁹

This decline in DNA repair efficiency can contribute to age-related diseases and accelerated aging.¹⁰

By supplementing with NAD+ precursors like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), it may be possible to boost NAD+ levels and improve DNA repair, potentially slowing down the aging process.¹¹

Conclusion

NAD+ is an essential molecule for maintaining cellular health and longevity.¹²

Its role in DNA repair is particularly important, as it helps protect our genetic material from damage.¹³

By understanding the intricate relationship between NAD+ and DNA repair, scientists are gaining valuable insights into the aging process and developing potential therapeutic strategies to combat age-related diseases.

What is NAD?